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Subependymal heterotopia has recently been recognized as a cause of epilepsy,but the clinical and investigational features have not been fully described.The clinical,psychometric,imaging,and electroencephalographic features of 13 adult patients with subependymal heterotopia and epilepsy have been reviewed.Onset of epilepsy in the second decade of life,normal developmental milestones and intelligence,and the finding of an overwhelming female preponderance differentiates subependymal heterotopia from other cortical dysgeneses.The female preponderance supports the importance of the X chromosomes and sex steroids in the maturation and development of the cerebral cortex. |
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